multivelo.LRT_decoupling

multivelo.LRT_decoupling(adata_rna, adata_atac, **kwargs)

Computes likelihood ratio test for decoupling state.

This function computes whether keeping decoupling state improves fit Likelihood.

Parameters:

  • adata_rna (AnnData) – RNA anndata object

  • adata_atac (AnnData) – ATAC anndata object.

  • recover_dynamics_chrom. (Additional parameters passed to) –

Returns:

  • adata_result_w_decoupled (class:~anndata.AnnData) – fit result with decoupling state

  • adata_result_w_decoupled (class:~anndata.AnnData) – fit result without decoupling state

  • res (pandas.DataFrame) – LRT statistics